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KMID : 0613820190290010112
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Journal of Life Science
2019 Volume.29 No. 1 p.112 ~ p.117
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Single Dose Oral Toxicity Test of Water Extract of Corni Fructus in ICR Mice
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Hwang Young-Hoon
Kwon Da-Hye
Kim Min-Young
Ji Seon-Yeong
Choi Eun-Ok
Kim Sung-Ok
Jeung Ji-Suk
Hong Su-Hyun
Choi Sung-Hyun
Park Cheol
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Abstract
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Herbal medicines are widely used as therapeutic products in many countries. Corni fructus (CF), the dried ripe sarcocarp of Cornus officinalis Sieb. et Zucc (Cornaceae), has been used for thousands of years in traditional medicine and has been reported to be effective for the prevention and treatment of various diseases, such as kidney diseases and diabetes. Recent research on CF has documented a wide spectrum of therapeutic properties, which include anti-inflammatory, ant-oxidative, immunomodulatory, and anti-cancer effects. However, there is no information on its safety. Therefore, in this study, the toxicity of water extract of CF to ICR mice was investigated. The mice received a single dose of water extract of CF (1,000, 2,000, and 5,000 mg/kg of body weight) via the oral route. Mortality, clinical signs, body weight changes, gross findings, and weights of the principal organs after 14 d were then assessed. The results revealed no adverse effects of CF as determined by clinical signs, body weights, or organ weights and no gross pathological findings in any of the treatment groups. These results suggest that the 50% lethal dose and approximated lethal dose of CF extract is over 5,000 mg/kg. The findings provide scientific evidence for the safety of CFs.
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KEYWORD
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Corni Fructus, ICR mice, single dose oral toxicity, safety
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